|
KMID : 0350519930460030985
|
|
Journal of Catholic Medical College
1993 Volume.46 No. 3 p.985 ~ p.995
|
|
|
Colposcopic Use for Early Diagnosis in Cervical Neoplasic Lesions
|
|
|
|
|
Abstract
|
|
|
Colposcopic signs of demarcation, surface contour, color change and abnormal vessels of the cervical lesions of two hundreds and seventy four patients, who were entered into study, were graded into three objective categories representing
subclinical
papillomaviral infection, CIN Ⅰ-Ⅱand CIN Ⅲand over by scoring. And these were evaluated by histology of benign warty change, presumed viral atypia, abnormal cell phenotype and disturbed tissue maturation to evaluate the accuracy of this
colposcopic
differentiation between the different histologic grades of lesions by scoring.
In this study, we used the modified colposcopic indices excluding the ioding stain. The lesions with minor colposcopic signs, which were scored below 2, were attributable to human papillomaviral disturbance of cell growth and maturation, which
were
seen
histologically as parabasal layer proliferation, papillomatosis, koilocytosis, and dyskeratosis. Major colposcopic abnormalities, which wfere scored 6 and over, reflect extensive disorganization of cell phenotype and tissue architecture.
Intermediate
colposcopic patterns, which had scores between 3 and 5, generally denote the reciprocal tissue changes of a composite of the benign warty expression and the premalignant change. We also observed that a highly significant statistical relationship
exist
between subclinical papillomaviral infection of the uterine cervix and the occurrence of cervrcal neoplasia correlated by colposcopic signs and histologic indices(Ⅹ*=268.29, P=0.000).
In the colposcopic diagnosis for subclinical papillomaviral infection, we observed that the sensitivity and specificity were 90.5% and 94.95% and the positive and negative predictive value were 94.7% and 90.9%, respectively. The sensitivity and
specificity for CIN Ⅲ and/or above were 78.2% and 94.4% and the positive and negative predictive value were 97.5% and 60.7%, respectively.
These results suggest that the colposcopic scoring is very useful for the diagnosis and differentiation of the various cervical lesions.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|